Ticagrelor-induced acute kidney injury can increase serum concentration of statin and lead to concurrence of rhabdomyolysis
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چکیده
The 2016 American Heart Association/American College of Cardiology guidelines advise the use of dual antiplatelet agents for patients with acute coronary syndrome (ACS) (1). Ticagrelor is a reversible oral antagonist of the ADP receptor P2Y12. It is rapidly absorbed and metabolized by cytochrome P450 (CYP) 3A4. Therefore, ticagrelor suggests a potential for drug interactions with other CYP3A4 substrates (2). Statins are recommended for preventing cardiovascular disease after ACS (3). These statins are associated with myalgia; elevation of creatine phosphokinase (CK) concentrations; and rarely, rhabdomyolysis. Rhabdomyolysis caused by statins is susceptible to occur when the renal function is impaired (4). Here we describe a patient in whom ticagrelor-induced acute kidney injury (AKI) increased the serum concentration of statin and then, eventually, led to concurrence of rhabdomyolysis.
منابع مشابه
A Unique Case of Drug Interaction between Ticagrelor and Statin Leading to Acute Renal Failure
Dual antiplatelet agents and high-intensity statins are frequently used in combination after myocardial infarction. Ticagrelor has the potential of causing acute kidney injury. Rosuvastatin is excreted through the kidneys and dose adjustment is needed in patients with kidney disease. When used in combination, they can potentiate the toxic effects of each other. We report a case of drug interact...
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